LIAS, lipoic acid synthetase

LIAS, lipoic acid synthetase

• The protein encoded by this gene belongs to the biotin and lipoic acid synthetases family. It localizes in mitochondrion and plays an important role in alpha-(+)-lipoic acid synthesis. It may also function in the sulfur insertion chemistry in lipoate biosynthesis. Alternative splicing occurs at this locus and two transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008]

• Gene Synonyms (HGCLAS, HUSSY-01, LAS, LIP1, LS, PDHLD, lipoyl synthase, mitochondrial, lip-syn, lipoate synthase,)
• NCBI Gene ID: 11019
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q6P5Q6
  UNIPROT ID#>>A0A024R9W0
  UNIPROT ID#>>O43766
  UNIPROT ID#>>B4E0L7
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

lipoic acid synthetase interacts with:

• 2-oxoglutarate and iron dependent oxygenase domain containing 1
  cyclin dependent kinase 12
  HscB mitochondrial iron-sulfur cluster cochaperone
  lipoic acid synthetase
  mediator complex subunit 10
  ribosomal protein L35
  ring finger protein 123
  SEH1 like nucleoporin
  ZW10 interacting kinetochore protein

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.