UHRF2, ubiquitin like with PHD and ring finger domains 2

UHRF2, ubiquitin like with PHD and ring finger domains 2

• This gene encodes a nuclear protein which is involved in cell-cycle regulation. The encoded protein is a ubiquitin-ligase capable of ubiquinating PCNP (PEST-containing nuclear protein), and together they may play a role in tumorigenesis. The encoded protein contains an NIRF_N domain, a PHD finger, a set- and ring-associated (SRA) domain, and a RING finger domain and several of these domains have been shown to be essential for the regulation of cell proliferation. This protein may also have a role in intranuclear degradation of polyglutamine aggregates. Alternative splicing results in multiple transcript variants some of which are non-protein coding. [provided by RefSeq, Feb 2012]

• Gene Synonyms (NIRF, RNF107, TDRD23, URF2, E3 ubiquitin-protein ligase UHRF2, Np95-like ring finger protein, RING finger protein 107, RING-type E3 ubiquitin transferase UHRF2, np95/ICBP90-like RING finger protein, nuclear protein 97, nuclear zinc finger protein NP97, ubiquitin-like PHD and RING finger domain-containing protein 2, ubiquitin-like with PHD and ring finger domains 2, E3 ubiquitin protein ligase, ubiquitin-like, containing PHD and RING finger domains, 2, ubiquitin-like-containing PHD and RING finger domains protein 2,)
• NCBI Gene ID: 115426
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q96PU4
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

ubiquitin like with PHD and ring finger domains 2 interacts with:

• cyclin dependent kinase 11A
  ubiquitin like with PHD and ring finger domains 2

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