Mbd3, methyl-CpG binding domain protein 3

Mbd3, methyl-CpG binding domain protein 3

• This gene encodes a member of the MBD family of nuclear proteins that contain a methyl-CpG binding domain (MBD). The encoded protein is a component of the nucleosome remodeling and histone deacetylation (NuRD) complex. Deletion of this gene causes embryonic lethality in mice. Embryonic stem cells lacking the encoded protein are severely compromised in their ability to differentiate and fail to commit to developmental lineages in the absence of leukemia inhibitory factor. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]

• (No alternate names found)
• NCBI Gene ID: 17192
• Species: Mus musculus (Mouse)
• UNIPROT ID#>>Q9Z2D8
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

methyl-CpG binding domain protein 3 interacts with:

• chromodomain helicase DNA binding protein 4
  chromodomain helicase DNA binding protein 5
  estrogen related receptor, beta
  euchromatic histone lysine N-methyltransferase 2
  L3MBTL2 polycomb repressive complex 1 subunit
  metastasis associated 1
  metastasis-associated gene family, member 2
  Nanog homeobox
  POU domain, class 5, transcription factor 1
  spalt like transcription factor 4
  transcription factor CP2-like 1
  transcription factor E3
  zinc finger and BTB domain containing 7B

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.