Per1, period circadian clock 1

Per1, period circadian clock 1

• This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. This gene is upregulated by Clock/Arntl heterodimers but then represses this upregulation in a feedback loop using Per/Cry heterodimers to interact with Clock/Arntl. Polymorphisms in this gene may increase the risk of getting certain cancers. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jan 2014]

• (No alternate names found)
• NCBI Gene ID: 18626
• Species: Mus musculus (Mouse)
• UNIPROT ID#>>O35973
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

period circadian clock 1 interacts with:

• casein kinase 1, delta
  casein kinase 1, epsilon
  family with sequence similarity 110, member B
  FERM, RhoGEF and pleckstrin domain protein 2
  forkhead box P1
  non-POU-domain-containing, octamer binding protein
  period circadian clock 1
  period circadian clock 2
  period circadian clock 3
  splicing factor proline/glutamine rich (polypyrimidine tract binding protein associated)
  storkhead box 2
  T cell leukemia, homeobox 3
  timeless circadian clock 1
  transcriptional regulator, SIN3A (yeast)
  ubiquitin specific peptidase 2

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.