Tfap2a, transcription factor AP-2, alpha

Tfap2a, transcription factor AP-2, alpha

• This gene is a member of the activator protein 2 (AP-2) transcription factor family. The protein encoded by this gene can act as both an activator and repressor of gene transcription, and plays an important role in early embryogenesis, specifically in cranial development. This protein forms both homodimers and heterodimers, and binds to a GC-rich consensus sequence found in some promoters and enhancers. Disruption of this gene causes perinatal death, with neural tube, craniofacial, and limb mesenchyme defects. Alternative splicing results in multiple transcript variants that encode multiple protein isoforms. [provided by RefSeq, Sep 2014]

• (No alternate names found)
• NCBI Gene ID: 21418
• Species: Mus musculus (Mouse)
• UNIPROT ID#>>Q8BPN4
  UNIPROT ID#>>P34056
  UNIPROT ID#>>A0A286YCU0
  UNIPROT ID#>>A0A286YD43
  UNIPROT ID#>>Q3UL09
  UNIPROT ID#>>A0A0R4J1E6
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

transcription factor AP-2, alpha interacts with:

• ring finger protein 20
  single stranded DNA binding protein 4
  transcription factor AP-2, alpha
  transcription factor AP-2, delta

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.