SASH1, SAM and SH3 domain containing 1

SASH1, SAM and SH3 domain containing 1

• This gene encodes a scaffold protein involved in the TLR4 signaling pathway that may stimulate cytokine production and endothelial cell migration in response to invading pathogens. The encoded protein has also been described as a potential tumor suppressor that may negatively regulate proliferation, apoptosis, and invasion of cancer cells, and reduced expression of this gene has been observed in multiple human cancers. Mutations in this gene may be associated with abnormal skin pigmentation in human patients. [provided by RefSeq, Oct 2016]

• Gene Synonyms (CAPOK, DUH1, SH3D6A, dJ323M4.1, SAM and SH3 domain-containing protein 1, proline-glutamate repeat-containing protein,)
• NCBI Gene ID: 23328
• Species: Homo sapiens (Human)
• UNIPROT ID#>>O94885
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

SAM and SH3 domain containing 1 interacts with:

• activating signal cointegrator 1 complex subunit 2
  cyclin D1 binding protein 1
  EPS8 like 2
  exocyst complex component 8
  interleukin 1 receptor associated kinase 4
  jade family PHD finger 2
  RNA binding motif protein 12B
  suppressor of variegation 3-9 homolog 2
  tankyrase 2
  vir like m6A methyltransferase associated

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.