QPRT, quinolinate phosphoribosyltransferase

QPRT, quinolinate phosphoribosyltransferase

• This gene encodes a key enzyme in catabolism of quinolinate, an intermediate in the tryptophan-nicotinamide adenine dinucleotide pathway. Quinolinate acts as a most potent endogenous exitotoxin to neurons. Elevation of quinolinate levels in the brain has been linked to the pathogenesis of neurodegenerative disorders such as epilepsy, Alzheimer's disease, and Huntington's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]

• Gene Synonyms (nicotinate-nucleotide pyrophosphorylase [carboxylating], epididymis secretory sperm binding protein Li 90n, nicotinate-nucleotide pyrophosphorylase (carboxylating), HEL-S-90n, QPRTase,)
• NCBI Gene ID: 23475
• Species: Homo sapiens (Human)
• UNIPROT ID#>>B4DDH4
  UNIPROT ID#>>Q15274
  UNIPROT ID#>>V9HWJ5
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

quinolinate phosphoribosyltransferase interacts with:

• actin related protein 6
  ADAMTS like 4
  AT-rich interaction domain 1B
  BCL6 corepressor
  cell division cycle and apoptosis regulator 1
  DNA methyltransferase 1 associated protein 1
  FKBP prolyl isomerase 10
  GATA zinc finger domain containing 2B
  GrpE like 1, mitochondrial
  interferon regulatory factor 2 binding protein 1
  isoleucyl-tRNA synthetase 2, mitochondrial
  keratin 40
  keratin associated protein 10-3
  keratin associated protein 10-8
  keratin associated protein 1-1
  keratin associated protein 4-12
  MIA SH3 domain ER export factor 3
  mitochondria localized glutamic acid rich protein
  N-acetylneuraminate pyruvate lyase
  neuroligin 3
  notch 2 N-terminal like A
  PAT1 homolog 1, processing body mRNA decay factor
  quinolinate phosphoribosyltransferase
  ribonucleoprotein, PTB binding 2
  SEH1 like nucleoporin
  SMAD specific E3 ubiquitin protein ligase 2
  SR-related CTD associated factor 4
  SUFU negative regulator of hedgehog signaling
  TBL1X receptor 1
  tripartite motif containing 33

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.