CBLC, Cbl proto-oncogene C

CBLC, Cbl proto-oncogene C

• This gene encodes a member of the Cbl family of E3 ubiquitin ligases. Cbl proteins play important roles in cell signaling through the ubiquitination and subsequent downregulation of tyrosine kinases. Expression of this gene may be restricted to epithelial cells, and alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2012]

• Gene Synonyms (E3 ubiquitin-protein ligase CBL-C, Cas-Br-M (murine) ecotropic retroviral transforming sequence c, Cas-Br-M (murine) ectropic retroviral transforming sequence c, Cbl proto-oncogene C, E3 ubiquitin protein ligase, Cbl proto-oncogene, E3 ubiquitin protein ligase C, RING finger protein 57, RING-type E3 ubiquitin transferase CBL-C, SH3-binding protein CBL-3, SH3-binding protein CBL-C, signal transduction protein CBL-C, CBL-3, CBL-SL, RNF57,)
• NCBI Gene ID: 23624
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q9ULV8
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

Cbl proto-oncogene C interacts with:

• BRICK1 subunit of SCAR/WAVE actin nucleating complex
  checkpoint with forkhead and ring finger domains
  cytoplasmic FMR1 interacting protein 2
  GLIS family zinc finger 2
  itchy E3 ubiquitin protein ligase
  large tumor suppressor kinase 2
  mitochondrial genome maintenance exonuclease 1
  nuclear receptor binding SET domain protein 3
  OTU deubiquitinase 6A
  tripartite motif containing 46
  ubiquitin conjugating enzyme E2 R2
  ubiquitin specific peptidase 21

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.