CHFR, checkpoint with forkhead and ring finger domains

CHFR, checkpoint with forkhead and ring finger domains

• This gene encodes an E3 ubiquitin-protein ligase required for the maintenance of the antephase checkpoint that regulates cell cycle entry into mitosis and, therefore, may play a key role in cell cycle progression and tumorigenesis. The encoded protein has an N-terminal forkhead-associated domain, a central RING-finger domain, and a cysteine-rich C-terminal region. Alternatively spliced transcript variants that encode different protein isoforms have been described. [provided by RefSeq, Mar 2014]

• Gene Synonyms (RNF116, RNF196, E3 ubiquitin-protein ligase CHFR, RING finger protein 196, RING-type E3 ubiquitin transferase CHFR, checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase,)
• NCBI Gene ID: 55743
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q96EP1
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

checkpoint with forkhead and ring finger domains interacts with:

• checkpoint with forkhead and ring finger domains
  chromosome 5 open reading frame 24
  deltex E3 ubiquitin ligase 3
  PDZ binding kinase
  tripartite motif containing 9

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