PRKD3, protein kinase D3

PRKD3, protein kinase D3

• This gene belongs to the multigene protein kinase D family of serine/threonine kinases, which bind diacylglycerol and phorbol esters. Members of this family are characterized by an N-terminal regulatory domain comprised of a tandem repeat of cysteine-rich zinc-finger motifs and a pleckstrin domain. The C-terminal region contains the catalytic domain and is distantly related to calcium-regulated kinases. Catalytic activity of this enzyme promotes its nuclear localization. This protein has been implicated in a variety of functions including negative regulation of human airway epithelial barrier formation, growth regulation of breast and prostate cancer cells, and vesicle trafficking. [provided by RefSeq, Jan 2015]

• Gene Synonyms (serine/threonine-protein kinase D3, protein kinase C nu type, protein kinase EPK2, EPK2, PKC-NU, PKD3, PRKCN, nPKC-NU,)
• NCBI Gene ID: 23683
• Species: Homo sapiens (Human)
• UNIPROT ID#>>O94806
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

protein kinase D3 interacts with:

• catenin, beta like 1
  DNA polymerase lambda
  pleckstrin homology domain containing A4
  protein kinase D2
  spindle and kinetochore associated complex subunit 2
  vir like m6A methyltransferase associated

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.