ARHGAP8, Rho GTPase activating protein 8

ARHGAP8, Rho GTPase activating protein 8

• This gene encodes a member of the RHOGAP family. GAP (GTPase-activating) family proteins participate in signaling pathways that regulate cell processes involved in cytoskeletal changes. GAP proteins alternate between an active (GTP-bound) and inactive (GDP-bound) state based on the GTP:GDP ratio in the cell. This family member is a multidomain protein that functions to promote Erk activation and cell motility. Alternative splicing results in multiple transcript variants. Read-through transcripts from the upstream proline rich 5, renal (PRR5) gene into this gene also exist, which led to the original description of PRR5 and ARHGAP8 being a single gene. [provided by RefSeq, Nov 2010]

• Gene Synonyms (rho GTPase-activating protein 8, BCH domain-containing Cdc42GAP-like protein, BNIP-2 and Cdc42GAP homology domain-containing, proline-rich and Cdc42GAP-like protein subtype-1, rho-type GTPase-activating protein 8, BPGAP1, PP610,)
• NCBI Gene ID: 23779
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q6PJW1
  UNIPROT ID#>>P85298
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

Rho GTPase activating protein 8 interacts with:

• 5-hydroxytryptamine receptor 3C
  cytoglobin
  isochorismatase domain containing 1
  leucine rich repeat containing 10
  PRR5-ARHGAP8 readthrough
  Rho GTPase activating protein 8
  zinc finger MYND-type containing 12

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.