NPHP4, nephrocystin 4

NPHP4, nephrocystin 4

• This gene encodes a protein involved in renal tubular development and function. This protein interacts with nephrocystin, and belongs to a multifunctional complex that is localized to actin- and microtubule-based structures. Mutations in this gene are associated with nephronophthisis type 4, a renal disease, and with Senior-Loken syndrome type 4, a combination of nephronophthisis and retinitis pigmentosa. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]

• Gene Synonyms (nephrocystin-4, POC10 centriolar protein homolog, nephroretinin, POC10, SLSN4,)
• NCBI Gene ID: 261734
• Species: Homo sapiens (Human)
• UNIPROT ID#>>B3KW36
  UNIPROT ID#>>O75161
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

nephrocystin 4 interacts with:

• IQ motif containing GTPase activating protein 3
  nephrocystin 4
  tubulin beta 2B class IIb

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.