SOX8, SRY-box transcription factor 8

SOX8, SRY-box transcription factor 8

• This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional activator after forming a protein complex with other proteins. This protein may be involved in brain development and function. Haploinsufficiency for this protein may contribute to the cognitive disability found in an alpha-thalassemia-related syndrome (ART-16). This protein is also highly expressed in the majority of human hepatocellular carcinomas and promotes cellular proliferation and enhanced tumor growth. [provided by RefSeq, Jul 2017]

• Gene Synonyms (transcription factor SOX-8, SRY (sex determining region Y)-box 8, SRY-box 8,)
• NCBI Gene ID: 30812
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P57073
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

SRY-box transcription factor 8 interacts with:

• junctional adhesion molecule 2
  p53-induced death domain protein 1

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.