CD209, CD209 molecule

CD209, CD209 molecule

• This gene encodes a C-type lectin that functions in cell adhesion and pathogen recognition. This receptor recognizes a wide range of evolutionarily divergent pathogens with a large impact on public health, including leprosy and tuberculosis mycobacteria, the Ebola, hepatitis C, HIV-1 and Dengue viruses, and the SARS-CoV acute respiratory syndrome coronavirus. The protein is organized into four distinct domains: a C-terminal carbohydrate recognition domain, a flexible tandem-repeat neck domain, a transmembrane region and an N-terminal cytoplasmic domain involved in internalization. This gene is closely related in terms of both sequence and function to a neighboring gene, CLEC4M (Gene ID: 10332), also known as L-SIGN. The two genes differ in viral recognition and expression patterns, with this gene showing high expression on the surface of dendritic cells. Polymorphisms in the neck region are associated with protection from HIV-1 infection, while single nucleotide polymorphisms in the promoter of this gene are associated with differing resistance and susceptibility to and severity of infectious disease, including rs4804803, which is associated with SARS severity. [provided by RefSeq, May 2020]

• Gene Synonyms (CD209 antigen, C-type lectin domain family 4 member L, HIV gpl20-binding protein, dendritic cell-specific ICAM-3-grabbing non-integrin 1, dendritic cell-specific intercellular adhesion molecule-3-grabbing non-integrin, dendritic cell-specific intracellular adhesion molecules (ICAM)-3 grabbing non-integrin, CDSIGN, CLEC4L, DC-SIGN, DC-SIGN1,)
• NCBI Gene ID: 30835
• Species: Homo sapiens (Human)
• UNIPROT ID#>>X6RB12
  UNIPROT ID#>>Q9NNX6
  UNIPROT ID#>>B2R907
  UNIPROT ID#>>M0R0P0
  UNIPROT ID#>>B4E2A8
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

CD209 molecule interacts with:

• CD209 molecule
  family with sequence similarity 217 member B
  intraflagellar transport 20
  kelch like family member 26
  transcription elongation factor A like 8
  VAC14 component of PIKFYVE complex
  zinc finger protein 703

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.