IDH3G, isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit gamma

IDH3G, isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit gamma

• Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. NAD(+)-dependent isocitrate dehydrogenases catalyze the allosterically regulated rate-limiting step of the tricarboxylic acid cycle. Each isozyme is a heterotetramer that is composed of two alpha subunits, one beta subunit, and one gamma subunit. The protein encoded by this gene is the gamma subunit of one isozyme of NAD(+)-dependent isocitrate dehydrogenase. This gene is a candidate gene for periventricular heterotopia. Several alternatively spliced transcript variants of this gene have been described, but only some of their full length natures have been determined. [provided by RefSeq, Jul 2008]

• Gene Synonyms (isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial, IDH-gamma, NAD (H)-specific isocitrate dehydrogenase gamma subunit, NAD(+)-specific ICDH subunit gamma, NAD+-specific ICDH, isocitrate dehydrogenase (NAD(+)) 3 gamma, isocitrate dehydrogenase 3 (NAD(+)) gamma, isocitrate dehydrogenase 3 (NAD+) gamma, isocitrate dehydrogenase 3 gamma, isocitrate dehydrogenase, NAD(+)-specific, mitochondrial, gamma subunit, isocitric dehydrogenase subunit gamma, H-IDHG,)
• NCBI Gene ID: 3421
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P51553
  UNIPROT ID#>>O15384
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit gamma interacts with:

• activator of HSP90 ATPase activity 1
  alkylglycerone phosphate synthase
  BCL6 corepressor
  CDV3 homolog
  endothelial differentiation related factor 1
  karyopherin subunit alpha 2
  MYC proto-oncogene, bHLH transcription factor
  pleckstrin homology domain containing A4
  polyglutamine binding protein 1
  POU class 5 homeobox 1
  protein phosphatase 1 regulatory subunit 12A
  RAB8A, member RAS oncogene family
  SBDS ribosome maturation factor
  sepiapterin reductase
  sterol carrier protein 2
  SURP and G-patch domain containing 1
  translocase of inner mitochondrial membrane 44

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