ITIH2, inter-alpha-trypsin inhibitor heavy chain 2

ITIH2, inter-alpha-trypsin inhibitor heavy chain 2

• The inter-alpha-trypsin inhibitors (ITI) are a family of structurally related plasma serine protease inhibitors involved in extracellular matrix stabilization and in prevention of tumor metastasis. The ITI family contains multiple proteins made up of a light chain (see MIM 176870) and a variable number of heavy chains (Salier et al., 1987 [PubMed 2446322]; Himmelfarb et al., 2004 [PubMed 14744536]).[supplied by OMIM, Nov 2009]

• Gene Synonyms (H2P, SHAP, inter-alpha-trypsin inhibitor heavy chain H2, ITI heavy chain H2, ITI-HC2, inter-alpha (globulin) inhibitor H2, inter-alpha (globulin) inhibitor, H2 polypeptide, inter-alpha-inhibitor heavy chain 2, inter-alpha-trypsin inhibitor complex component II, serum-derived hyaluronan-associated protein,)
• NCBI Gene ID: 3698
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P19823
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

inter-alpha-trypsin inhibitor heavy chain 2 interacts with:

• angiopoietin like 4
  CEA cell adhesion molecule 21
  dickkopf like acrosomal protein 1
  glycerophosphodiester phosphodiesterase domain containing 1
  H3 clustered histone 1
  inter-alpha-trypsin inhibitor heavy chain 2
  lipase G, endothelial type
  neurexophilin 2
  serine peptidase inhibitor, Kunitz type 2
  tumor necrosis factor
  ubiquitin protein ligase E3 component n-recognin 7
  UDP-glucose glycoprotein glucosyltransferase 2
  zymogen granule protein 16B

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.