LETM1, leucine zipper and EF-hand containing transmembrane protein 1

LETM1, leucine zipper and EF-hand containing transmembrane protein 1

• This gene encodes a protein that is localized to the inner mitochondrial membrane. The protein functions to maintain the mitochondrial tubular shapes and is required for normal mitochondrial morphology and cellular viability. Mutations in this gene cause Wolf-Hirschhorn syndrome, a complex malformation syndrome caused by the deletion of parts of the distal short arm of chromosome 4. Related pseudogenes have been identified on chromosomes 8, 15 and 19. [provided by RefSeq, Oct 2009]

• Gene Synonyms (SLC55A1, mitochondrial proton/calcium exchanger protein, LETM1 and EF-hand domain-containing protein 1, mitochondrial, Mdm38 homolog, leucine zipper-EF-hand containing transmembrane protein 1,)
• NCBI Gene ID: 3954
• Species: Homo sapiens (Human)
• UNIPROT ID#>>O95202
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

leucine zipper and EF-hand containing transmembrane protein 1 interacts with:

• acyl-CoA thioesterase 9
  alkylglycerone phosphate synthase
  apoptosis inducing factor mitochondria associated 1
  ATPase H+ transporting V0 subunit d1
  aurora kinase A interacting protein 1
  chromosome 12 open reading frame 57
  chromosome 15 open reading frame 48
  coenzyme Q9
  C-type lectin domain containing 14A
  cytochrome b5 reductase 1
  cytochrome c oxidase assembly factor COX14
  developmental pluripotency-associated 3
  elongation factor Tu GTP binding domain containing 2
  interferon induced transmembrane protein 3
  keratin associated protein 6-2
  large tumor suppressor kinase 2
  LY6/PLAUR domain containing 4
  mitochondrial ribosomal protein S11
  mitochondrial rRNA methyltransferase 1
  mitogen-activated protein kinase 6
  NDUFA4 mitochondrial complex associated
  neurotrophic receptor tyrosine kinase 1
  oxoglutarate dehydrogenase
  pleckstrin homology domain containing A4
  prolactin regulatory element binding
  proteasome 20S subunit alpha 3
  protein phosphatase, Mg2+/Mn2+ dependent 1A
  protein tyrosine phosphatase mitochondrial 1
  protocadherin gamma subfamily B, 4
  pyruvate dehydrogenase kinase 1
  RAB5B, member RAS oncogene family
  RAB7A, member RAS oncogene family
  ring finger protein 19B
  ring finger protein 4
  saccharopine dehydrogenase (putative)
  sideroflexin 1
  small nuclear ribonucleoprotein U4/U6.U5 subunit 27
  synaptotagmin binding cytoplasmic RNA interacting protein
  synthesis of cytochrome C oxidase 1
  TANK binding kinase 1
  tRNA methyltransferase 61B
  ubiquilin 1
  ubiquilin 2
  ubiquitin specific peptidase 47
  unc-93 homolog B1, TLR signaling regulator
  vir like m6A methyltransferase associated
  zinc finger protein 76

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.