MBL2, mannose binding lectin 2

MBL2, mannose binding lectin 2

• This gene encodes the soluble mannose-binding lectin or mannose-binding protein found in serum. The protein encoded belongs to the collectin family and is an important element in the innate immune system. The protein recognizes and binds to mannose and N-acetylglucosamine on many microorganisms, including bacteria, yeast, and viruses including influenza virus, HIV and SARS-CoV. This binding activates the classical complement pathway. Deficiencies of this gene have been associated with susceptibility to autoimmune and infectious diseases. [provided by RefSeq, Jun 2020]

• Gene Synonyms (COLEC1, HSMBPC, MBL, MBL2D, MBP, MBP-C, MBP1, MBPD, mannose-binding protein C, collectin-1, mannan-binding lectin, mannose-binding lectin (protein C) 2, soluble (opsonic defect), mannose-binding lectin 2, soluble (opsonic defect),)
• NCBI Gene ID: 4153
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P11226
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

mannose binding lectin 2 interacts with:

• CD93 molecule
  mannan binding lectin serine peptidase 1
  mannan binding lectin serine peptidase 2
  mannose binding lectin 2
  protein tyrosine phosphatase receptor type C
  trafficking protein particle complex 2
  ubiquilin 2

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.