MMP13, matrix metallopeptidase 13

MMP13, matrix metallopeptidase 13

• This gene encodes a member of the peptidase M10 family of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded preproprotein is proteolytically processed to generate the mature protease. This protease cleaves type II collagen more efficiently than types I and III. It may be involved in articular cartilage turnover and cartilage pathophysiology associated with osteoarthritis. Mutations in this gene are associated with metaphyseal anadysplasia. This gene is part of a cluster of MMP genes on chromosome 11. [provided by RefSeq, Jan 2016]

• Gene Synonyms (CLG3, MANDP1, MDST, MMP-13, collagenase 3, matrix metalloproteinase 13 (collagenase 3),)
• NCBI Gene ID: 4322
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q53H33
  UNIPROT ID#>>P45452
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

matrix metallopeptidase 13 interacts with:

• ADAM metallopeptidase with thrombospondin type 1 motif 5
  brevican
  C-C motif chemokine ligand 7
  F-box protein 7
  matrix metallopeptidase 13
  matrix metallopeptidase 14
  TIMP metallopeptidase inhibitor 3

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.