NCF4, neutrophil cytosolic factor 4

NCF4, neutrophil cytosolic factor 4

• The protein encoded by this gene is a cytosolic regulatory component of the superoxide-producing phagocyte NADPH-oxidase, a multicomponent enzyme system important for host defense. This protein is preferentially expressed in cells of myeloid lineage. It interacts primarily with neutrophil cytosolic factor 2 (NCF2/p67-phox) to form a complex with neutrophil cytosolic factor 1 (NCF1/p47-phox), which further interacts with the small G protein RAC1 and translocates to the membrane upon cell stimulation. This complex then activates flavocytochrome b, the membrane-integrated catalytic core of the enzyme system. The PX domain of this protein can bind phospholipid products of the PI(3) kinase, which suggests its role in PI(3) kinase-mediated signaling events. The phosphorylation of this protein was found to negatively regulate the enzyme activity. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]

• Gene Synonyms (CGD3, NCF, P40PHOX, SH3PXD4, neutrophil cytosol factor 4, NCF-4, SH3 and PX domain-containing protein 4, neutrophil NADPH oxidase factor 4, neutrophil cytosolic factor 4, 40kDa, p40-phox,)
• NCBI Gene ID: 4689
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q15080
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

neutrophil cytosolic factor 4 interacts with:

• coronin 1A
  neutrophil cytosolic factor 1
  protein kinase C delta
  protein kinase, DNA-activated, catalytic subunit
  thioredoxin

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