PRKDC, protein kinase, DNA-activated, catalytic subunit

PRKDC, protein kinase, DNA-activated, catalytic subunit

• This gene encodes the catalytic subunit of the DNA-dependent protein kinase (DNA-PK). It functions with the Ku70/Ku80 heterodimer protein in DNA double strand break repair and recombination. The protein encoded is a member of the PI3/PI4-kinase family.[provided by RefSeq, Jul 2010]

• Gene Synonyms (DNA-dependent protein kinase catalytic subunit, DNA-PK catalytic subunit, hyper-radiosensitivity of murine scid mutation, complementing 1, p460, protein kinase, DNA-activated, catalytic polypeptide, DNA-PKC, DNA-PKcs, DNAPK, DNAPKc, DNPK1, HYRC, HYRC1, IMD26, XRCC7, p350,)
• NCBI Gene ID: 5591
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P78527
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

protein kinase, DNA-activated, catalytic subunit interacts with:

• AAR2 splicing factor
  activation induced cytidine deaminase
  activator of HSP90 ATPase activity 1
  AKT interacting protein
  anaphase promoting complex subunit 2
  ankyrin repeat and SOCS box containing 5
  anterior gradient 2, protein disulphide isomerase family member
  ATR interacting protein
  autophagy related 101
  autophagy related 4C cysteine peptidase
  BAG cochaperone 3
  BCL2 like 14
  BCL2-associated athanogene 2
  beclin 1
  bromodomain containing 7
  C1D nuclear receptor corepressor
  calcium and integrin binding 1
  calcium/calmodulin dependent protein kinase kinase 2
  CCCTC-binding factor
  CDK5 regulatory subunit associated protein 2
  cell division cycle 73
  checkpoint kinase 2
  chromatin assembly factor 1 subunit A
  chromodomain helicase DNA binding protein 1 like
  coiled-coil domain containing 8
  COP9 signalosome subunit 5
  COPI coat complex subunit epsilon
  CTD phosphatase subunit 1
  CTP synthase 2
  cullin 3
  cullin 5
  cullin 7
  CWC27 spliceosome associated cyclophilin
  DDB1 and CUL4 associated factor 1
  DEAH-box helicase 38
  decapping enzyme, scavenger
  DET1 and DDB1 associated 1
  dicarbonyl and L-xylulose reductase
  DNA cross-link repair 1B
  DNA cross-link repair 1C
  DNA topoisomerase I
  DnaJ heat shock protein family (Hsp40) member C7
  egl-9 family hypoxia inducible factor 3
  EH domain containing 1
  elongation factor Tu GTP binding domain containing 2
  elongator complex protein 1
  embryonic ectoderm development
  eukaryotic translation initiation factor 2 subunit beta
  FAD dependent oxidoreductase domain containing 2
  Fas associated factor family member 2
  F-box protein 6
  fizzy and cell division cycle 20 related 1
  glutamate rich WD repeat containing 1
  H2A clustered histone 4
  H3 clustered histone 1
  H3 clustered histone 6
  H4 clustered histone 1
  HEXIM P-TEFb complex subunit 1
  histone deacetylase 11
  histone deacetylase 3
  histone deacetylase 5
  integrin alpha FG-GAP repeat containing 1
  IQ motif containing B1
  La ribonucleoprotein 7, transcriptional regulator
  leucine rich repeat containing G protein-coupled receptor 4
  leucine rich repeat kinase 2
  ligand of numb-protein X 1
  limb development membrane protein 1 like
  LRR binding FLII interacting protein 1
  lysine acetyltransferase 5
  lysine acetyltransferase 8
  MAPK interacting serine/threonine kinase 1
  mediator of DNA damage checkpoint 1
  membrane spanning 4-domains A4A
  methyltransferase like 14
  methyltransferase like 3
  mex-3 RNA binding family member C
  mitogen-activated protein kinase 8
  mitogen-activated protein kinase 9
  MSL complex subunit 3
  neutrophil cytosolic factor 1
  NK2 homeobox 1
  nuclear receptor coactivator 6
  nuclear receptor subfamily 1 group H member 4
  nuclear receptor subfamily 2 group C member 2
  nucleoporin 107
  nucleoporin 35
  nucleoporin 85
  obscurin like cytoskeletal adaptor 1
  p53-induced death domain protein 1
  pellino E3 ubiquitin protein ligase 1
  phosphoglycerate dehydrogenase
  phospholipase A2 group IVC
  phosphotriesterase related
  PIH1 domain containing 1
  pleckstrin homology domain containing A4
  poly(A) specific ribonuclease subunit PAN2
  polynucleotide kinase 3'-phosphatase
  pre-mRNA processing factor 8
  protection of telomeres 1
  protein kinase, DNA-activated, catalytic subunit
  protein phosphatase 6 regulatory subunit 1
  protein phosphatase 6 regulatory subunit 2
  protein phosphatase 6 regulatory subunit 3
  protein phosphatase 6, catalytic subunit
  protein phosphatase 6, regulatory subunit 1
  protein tyrosine phosphatase receptor type U
  PTEN induced kinase 1
  Rac/Cdc42 guanine nucleotide exchange factor 6
  RAD17 checkpoint clamp loader component
  RAD18 E3 ubiquitin protein ligase
  RAD21 cohesin complex component
  RAN binding protein 2
  Ras association domain family member 1
  RB binding protein 8, endonuclease
  receptor interacting serine/threonine kinase 4
  receptor like tyrosine kinase
  RecQ like helicase 4
  RecQ like helicase 5
  RELA proto-oncogene, NF-kB subunit
  replication factor C subunit 2
  replication protein A1
  replication protein A2
  replication protein A3
  required for meiotic nuclear division 5 homolog A
  ribonucleotide reductase regulatory subunit M2
  ribosomal protein S11
  ribosomal protein S6 kinase A2
  ring finger protein 123
  ring finger protein 144A
  ring finger protein 4
  ring-box 1
  RIO kinase 1
  RNA 2',3'-cyclic phosphate and 5'-OH ligase
  RNA binding motif protein 25
  RNA transcription, translation and transport factor
  RuvB like AAA ATPase 1
  RuvB like AAA ATPase 2
  RuvB-like protein 1
  RuvB-like protein 2
  serine and arginine rich splicing factor 10
  serum response factor
  SET domain containing 1A, histone lysine methyltransferase
  SHC adaptor protein 1
  shugoshin 1
  signal recognition particle 14
  signal recognition particle 54
  Sin3A associated protein 25
  sirtuin 6
  sirtuin 7
  SKI proto-oncogene
  small nuclear ribonucleoprotein polypeptide A
  small ubiquitin like modifier 2
  snail family transcriptional repressor 1
  SNW domain containing 1
  solute carrier family 15 member 3
  solute carrier family 25 member 1
  somatostatin receptor 4
  Sp1 transcription factor
  spindle apparatus coiled-coil protein 1
  splicing factor 3b subunit 6
  staufen double-stranded RNA binding protein 1
  SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5
  SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1
  TELO2 interacting protein 1
  TELO2 interacting protein 2
  telomere maintenance 2
  telomeric repeat binding factor 1
  telomeric repeat binding factor 1
  TERF1 interacting nuclear factor 2
  testin LIM domain protein
  thioesterase superfamily member 6
  THO complex 6
  thymocyte nuclear protein 1
  thymopoietin
  thyroid hormone receptor alpha
  thyroid hormone receptor beta
  TNF superfamily member 13b
  transcription factor 7 like 2
  transcription factor CP2
  transformer 2 beta homolog
  transforming growth factor beta 1
  translocated promoter region, nuclear basket protein
  transmembrane phosphatase with tensin homology
  transmembrane protein 41B
  tripartite motif containing 25
  tripartite motif containing 28
  tripartite motif containing 29
  tumor protein p53
  tumor protein, translationally-controlled 1
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta
  U2 small nuclear RNA auxiliary factor 2
  UBA domain containing 2
  ubiquilin 2
  ubiquitin conjugating enzyme E2 I
  ubiquitin C-terminal hydrolase L3
  ubiquitin specific peptidase 14
  ubiquitin specific peptidase 18
  UBX domain protein 6
  unc-93 homolog B1, TLR signaling regulator
  upstream transcription factor 1
  vascular cell adhesion molecule 1
  vir like m6A methyltransferase associated
  von Hippel-Lindau tumor suppressor
  VRK serine/threonine kinase 1
  WD repeat domain 76
  WRN RecQ like helicase
  WW domain containing E3 ubiquitin protein ligase 1
  WW domain containing E3 ubiquitin protein ligase 2
  XPA, DNA damage recognition and repair factor
  X-ray repair cross complementing 1
  X-ray repair cross complementing 4
  X-ray repair cross complementing 5
  Yes1 associated transcriptional regulator
  YY1 transcription factor
  zinc finger and BTB domain containing 7A
  zinc finger CCCH-type containing 7A
  zinc finger protein 598, E3 ubiquitin ligase
  zinc finger protein 746

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.