NPR1, natriuretic peptide receptor 1

NPR1, natriuretic peptide receptor 1

• Guanylyl cyclases, catalyzing the production of cGMP from GTP, are classified as soluble and membrane forms (Garbers and Lowe, 1994 [PubMed 7982997]). The membrane guanylyl cyclases, often termed guanylyl cyclases A through F, form a family of cell-surface receptors with a similar topographic structure: an extracellular ligand-binding domain, a single membrane-spanning domain, and an intracellular region that contains a protein kinase-like domain and a cyclase catalytic domain. GC-A and GC-B function as receptors for natriuretic peptides; they are also referred to as atrial natriuretic peptide receptor A (NPR1) and type B (NPR2; MIM 108961). Also see NPR3 (MIM 108962), which encodes a protein with only the ligand-binding transmembrane and 37-amino acid cytoplasmic domains. NPR1 is a membrane-bound guanylate cyclase that serves as the receptor for both atrial and brain natriuretic peptides (ANP (MIM 108780) and BNP (MIM 600295), respectively).[supplied by OMIM, May 2009]

• Gene Synonyms (ANPRA, ANPa, GUC2A, GUCY2A, NPRA, atrial natriuretic peptide receptor 1, ANP-A, ANPR-A, GC-A, NPR-A, atrial natriuretic peptide receptor type A, atrionatriuretic peptide receptor A, guanylate cyclase A, natriuretic peptide A type receptor, natriuretic peptide receptor A, natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A), testicular tissue protein Li 20,)
• NCBI Gene ID: 4881
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P16066
  UNIPROT ID#>>A0A140VJE6
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

natriuretic peptide receptor 1 interacts with:

• activating transcription factor 7 interacting protein
  fructosamine 3 kinase
  metadherin
  natriuretic peptide receptor 1
  NDC80 kinetochore complex component
  protein kinase cAMP-activated catalytic subunit alpha
  protein kinase cGMP-dependent 1
  thioredoxin
  ubiquitin conjugating enzyme E2 D2

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