- Gene Overview
- Interaction Network
- Sequence Verification
NPR2, natriuretic peptide receptor 2
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This gene encodes natriuretic peptide receptor B, one of two integral membrane receptors for natriuretic peptides. Both NPR1 and NPR2 contain five functional domains: an extracellular ligand-binding domain, a single membrane-spanning region, and intracellularly a protein kinase homology domain, a helical hinge region involved in oligomerization, and a carboxyl-terminal guanylyl cyclase catalytic domain. The protein is the primary receptor for C-type natriuretic peptide (CNP), which upon ligand binding exhibits greatly increased guanylyl cyclase activity. Mutations in this gene are the cause of acromesomelic dysplasia Maroteaux type. [provided by RefSeq, Jul 2008]
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Gene Synonyms (AMDM, ANPRB, ANPb, ECDM, GC-B, GCB, GUC2B, GUCY2B, NPRB, NPRBi, SNSK, atrial natriuretic peptide receptor 2, atrial natriuretic peptide B-type receptor, atrial natriuretic peptide receptor type B, guanylate cyclase 2B, guanylate cyclase B, natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B),)
- NCBI Gene ID:
4882
- Species:
Homo sapiens (Human)
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UNIPROT ID#>>P20594
- View the NCBI Database
for this Gene »
Gene products are often involved in multiple pathways and networks within a living
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natriuretic peptide receptor 2 interacts with:
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