P2RX4, purinergic receptor P2X 4

P2RX4, purinergic receptor P2X 4

• The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel with high calcium permeability. The main pharmacological distinction between the members of the purinoceptor family is the relative sensitivity to the antagonists suramin and PPADS. The product of this gene has the lowest sensitivity for these antagonists. Multiple alternatively spliced transcript variants, some protein-coding and some not protein-coding, have been found for this gene. [provided by RefSeq, Feb 2012]

• Gene Synonyms (P2X4, P2X4R, P2X purinoceptor 4, ATP receptor, ATP-gated cation channel protein, P2X receptor, subunit 4, purinergic receptor P2X, ligand gated ion channel, 4, purinergic receptor P2X4, purinoceptor P2X4,)
• NCBI Gene ID: 5025
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q99571
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

purinergic receptor P2X 4 interacts with:

• armadillo repeat containing X-linked 3
  chondroitin sulfate N-acetylgalactosaminyltransferase 2
  coenzyme Q8B
  cytochrome b-245 chaperone 1
  DnaJ heat shock protein family (Hsp40) member C19
  dynein axonemal assembly factor 6
  ER membrane protein complex subunit 1
  ER membrane protein complex subunit 7
  eukaryotic translation initiation factor 2B subunit beta
  eukaryotic translation initiation factor 2B subunit delta
  eukaryotic translation initiation factor 2B subunit epsilon
  eukaryotic translation initiation factor 2B subunit gamma
  FAM20B glycosaminoglycan xylosylkinase
  glycosyltransferase 8 domain containing 1
  heparan sulfate 2-O-sulfotransferase 1
  keratin associated protein 1-1
  keratin associated protein 12-3
  NBPF member 19
  notch 2 N-terminal like A
  phosphatidylinositol glycan anchor biosynthesis class H
  phospholipase D family member 6
  post-GPI attachment to proteins GalNAc transferase 4
  serine palmitoyltransferase long chain base subunit 2
  serum amyloid A like 1
  signal peptide peptidase like 2B
  transportin 3
  Wnt family member 4

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.