PAPPA, pappalysin 1

PAPPA, pappalysin 1

• This gene encodes a secreted metalloproteinase which cleaves insulin-like growth factor binding proteins (IGFBPs). Following IGFBP cleavage, insulin growth factors dissociate from IGFBPs and bind to IGF receptors, resulting in activation of the IGF pathway. The encoded protein plays a role in bone formation, inflammation, wound healing and female fertility. Enhanced expression of this protein is associated with diabetic nephropathy in human patients and this protein may promote tumor invasion and growth in various human cancers. [provided by RefSeq, Aug 2017]

• Gene Synonyms (ASBABP2, DIPLA1, IGFBP-4ase, PAPA, PAPP-A, PAPPA1, pappalysin-1, IGF-dependent IGFBP-4 protease, aspecific BCL2 ARE-binding protein 2, differentially placenta 1 expressed protein, insulin-like growth factor-dependent IGF binding protein-4 protease, pregnancy-associated plasma protein A, pappalysin 1,)
• NCBI Gene ID: 5069
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q13219
  UNIPROT ID#>>B4DTA8
  UNIPROT ID#>>Q7Z613
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

pappalysin 1 interacts with:

• acidic nuclear phosphoprotein 32 family member A
  acidic nuclear phosphoprotein 32 family member E
  activating transcription factor 7 interacting protein
  pappalysin 1
  plasminogen
  proteoglycan 2, pro eosinophil major basic protein
  SKI like proto-oncogene
  troponin I3, cardiac type
  vir like m6A methyltransferase associated

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.