ATP6V1H, ATPase H+ transporting V1 subunit H

ATP6V1H, ATPase H+ transporting V1 subunit H

• This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of intracellular organelles. V-ATPase-dependent organelle acidification is necessary for multiple processes including protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. The encoded protein is the regulatory H subunit of the V1 domain of V-ATPase, which is required for catalysis of ATP but not the assembly of V-ATPase. Decreased expression of this gene may play a role in the development of type 2 diabetes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012]

• Gene Synonyms (V-type proton ATPase subunit H, ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H, V-ATPase 50/57 kDa subunits, V-ATPase subunit H, nef-binding protein 1, protein VMA13 homolog, vacuolar ATP synthase subunit H, vacuolar ATPase subunit H, vacuolar proton pump subunit H, vacuolar proton pump subunit SFD, CGI-11, MSTP042, NBP1, SFD, SFDalpha, SFDbeta, VMA13,)
• NCBI Gene ID: 51606
• Species: Homo sapiens (Human)
• UNIPROT ID#>>B3KUZ7
  UNIPROT ID#>>Q9UI12
  UNIPROT ID#>>A0A024R7U9
  UNIPROT ID#>>A0A024R7X3
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

ATPase H+ transporting V1 subunit H interacts with:

• acidic residue methyltransferase 1
  armadillo repeat containing 6
  charged multivesicular body protein 4B
  DEAD-box helicase 28
  egl-9 family hypoxia inducible factor 3
  flagellum associated containing coiled-coil domains 1
  limb development membrane protein 1 like
  mitochondrial ribosomal protein L1
  pleckstrin homology domain containing A4
  potassium channel tetramerisation domain containing 5
  protein phosphatase 1 regulatory subunit 12C
  regulator of microtubule dynamics 3
  solute carrier family 25 member 28
  striatin interacting protein 1
  ubiquitin specific peptidase 47
  unc-93 homolog B1, TLR signaling regulator
  unk zinc finger
  WD repeat domain 44

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.