PDK4, pyruvate dehydrogenase kinase 4

PDK4, pyruvate dehydrogenase kinase 4

• This gene is a member of the PDK/BCKDK protein kinase family and encodes a mitochondrial protein with a histidine kinase domain. This protein is located in the matrix of the mitrochondria and inhibits the pyruvate dehydrogenase complex by phosphorylating one of its subunits, thereby contributing to the regulation of glucose metabolism. Expression of this gene is regulated by glucocorticoids, retinoic acid and insulin. [provided by RefSeq, Jul 2008]

• Gene Synonyms (pyruvate dehydrogenase kinase, isozyme 4, [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial, [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 4, mitochondrial, pyruvate dehydrogenase kinase, isoenzyme 4, pyruvate dehydrogenase, lipoamide, kinase isozyme 4, mitochondrial,)
• NCBI Gene ID: 5166
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A4D1H4
  UNIPROT ID#>>Q16654
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

pyruvate dehydrogenase kinase 4 interacts with:

• asparaginyl-tRNA synthetase 2, mitochondrial
  pleckstrin homology and FYVE domain containing 2
  pyruvate dehydrogenase kinase 4
  tripartite motif containing 63

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.