MSRB1, methionine sulfoxide reductase B1

MSRB1, methionine sulfoxide reductase B1

• The protein encoded by this gene belongs to the methionine-R-sulfoxide reductase B (MsrB) family. Members of this family function as repair enzymes that protect proteins from oxidative stress by catalyzing the reduction of methionine-R-sulfoxides to methionines. This protein is highly expressed in liver and kidney, and is localized to the nucleus and cytosol. It is the only member of the MsrB family that is a selenoprotein, containing a selenocysteine (Sec) residue at its active site. It also has the highest methionine-R-sulfoxide reductase activity compared to other members containing cysteine in place of Sec. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. A pseudogene of this locus has been identified on chromosome 19. [provided by RefSeq, Aug 2017]

• Gene Synonyms (methionine-R-sulfoxide reductase B1, selenoprotein R, selenoprotein X, 1, HSPC270, SELR, SELX, SEPX1, SepR,)
• NCBI Gene ID: 51734
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q9NZV6
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

methionine sulfoxide reductase B1 interacts with:

• cysteine rich tail 1
  inhibitor of CDK, cyclin A1 interacting protein 1
  vitamin K epoxide reductase complex subunit 1

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