VKORC1, vitamin K epoxide reductase complex subunit 1

VKORC1, vitamin K epoxide reductase complex subunit 1

• This gene encodes the catalytic subunit of the vitamin K epoxide reductase complex, which is responsible for the reduction of inactive vitamin K 2,3-epoxide to active vitamin K in the endoplasmic reticulum membrane. Vitamin K is a required co-factor for carboxylation of glutamic acid residues by vitamin K-dependent gamma-carboxylase in blood-clotting enzymes. Allelic variation in this gene is associated with vitamin k-dependent clotting factors combined deficiency of 2, and increased resistance or sensitivity to warfarin, an inhibitor of vitamin K epoxide reductase. Pseudogenes of this gene are located on chromosomes 1 and X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]

• Gene Synonyms (vitamin K epoxide reductase complex subunit 1, phylloquinone epoxide reductase, vitamin K dependent clotting factors deficiency 2, vitamin K1 2,3-epoxide reductase subunit 1, vitamin K1 epoxide reductase (warfarin-sensitive), EDTP308, MST134, MST576, VKCFD2, VKOR,)
• NCBI Gene ID: 79001
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q9BQB6
  UNIPROT ID#>>A0A0S2Z6I4
  UNIPROT ID#>>A0A0S2Z5X7
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

vitamin K epoxide reductase complex subunit 1 interacts with:

• cAMP responsive element binding protein 3 like 1
  centrosomal protein 85-like
  coiled-coil domain containing 12
  coiled-coil domain containing 167
  complexin 4
  family with sequence similarity 209 member A
  family with sequence similarity 210 member B
  G protein-coupled receptor 152
  golgin, RAB6 interacting
  jagunal homolog 1
  methyltransferase like 7B
  potassium two pore domain channel subfamily K member 17
  serine palmitoyltransferase small subunit A
  transmembrane protein 120A
  transmembrane protein 134
  transmembrane protein 242
  transmembrane protein 256
  transmembrane protein 35B
  transmembrane protein 45B
  transmembrane serine protease 11B
  vitamin K epoxide reductase complex subunit 1
  vitamin K epoxide reductase complex subunit 1 like 1
  zinc finger CCHC-type containing 24

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.