SSH1, slingshot protein phosphatase 1

SSH1, slingshot protein phosphatase 1

• The protein encoded by this gene belongs to the slingshot homolog (SSH) family of phosphatases, which regulate actin filament dynamics. The SSH proteins dephosphorylate and activate the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Cofilin is inactivated by kinases such as LIM domain kinase-1 (LIMK1), which may also be dephosphorylated and inactivated by SSH proteins. The SSH family thus appears to play a role in actin dynamics by reactivating cofilin proteins. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]

• Gene Synonyms (protein phosphatase Slingshot homolog 1, SSH-like protein 1, hSSH-1L, slingshot homolog 1, SSH1L,)
• NCBI Gene ID: 54434
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q8WYL5
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

slingshot protein phosphatase 1 interacts with:

• actin beta like 2
  carboxypeptidase vitellogenic like
  COBW domain containing 1
  coronin 1B
  EF-hand domain family member D2
  KIAA1671
  protein phosphatase targeting COQ7
  scinderin
  slingshot protein phosphatase 1

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.