DDX4, DEAD-box helicase 4

DDX4, DEAD-box helicase 4

• DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is a homolog of VASA proteins in Drosophila and several other species. The gene is specifically expressed in the germ cell lineage in both sexes and functions in germ cell development. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]

• Gene Synonyms (probable ATP-dependent RNA helicase DDX4, DEAD (Asp-Glu-Ala-Asp) box polypeptide 4, DEAD box protein 4, DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 4, vasa homolog, VASA,)
• NCBI Gene ID: 54514
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q9NQI0
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

DEAD-box helicase 4 interacts with:

• cullin associated and neddylation dissociated 1
  methylphosphate capping enzyme
  mindbomb E3 ubiquitin protein ligase 1
  piwi like RNA-mediated gene silencing 2
  pleckstrin homology domain containing A4
  splA/ryanodine receptor domain and SOCS box containing 1
  splA/ryanodine receptor domain and SOCS box containing 2
  splA/ryanodine receptor domain and SOCS box containing 4

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.