RNF43, ring finger protein 43

RNF43, ring finger protein 43

• The protein encoded by this gene is a RING-type E3 ubiquitin ligase and is predicted to contain a transmembrane domain, a protease-associated domain, an ectodomain, and a cytoplasmic RING domain. This protein is thought to negatively regulate Wnt signaling, and expression of this gene results in an increase in ubiquitination of frizzled receptors, an alteration in their subcellular distribution, resulting in reduced surface levels of these receptors. Mutations in this gene have been reported in multiple tumor cells, including colorectal and endometrial cancers. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2015]

• Gene Synonyms (E3 ubiquitin-protein ligase RNF43, RING-type E3 ubiquitin transferase RNF43, RNF124, SSPCS, URCC,)
• NCBI Gene ID: 54894
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q68DV7
  UNIPROT ID#>>J3KSE3
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

ring finger protein 43 interacts with:

• limb development membrane protein 1 like
  myeloid associated differentiation marker
  ring finger protein 43
  R-spondin 1
  R-spondin 2

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.