NHP2, NHP2 ribonucleoprotein

NHP2, NHP2 ribonucleoprotein

• This gene is a member of the H/ACA snoRNPs (small nucleolar ribonucleoproteins) gene family. snoRNPs are involved in various aspects of rRNA processing and modification and have been classified into two families: C/D and H/ACA. The H/ACA snoRNPs also include the DKC1, NOLA1 and NOLA3 proteins. These four H/ACA snoRNP proteins localize to the dense fibrillar components of nucleoli and to coiled (Cajal) bodies in the nucleus. Both 18S rRNA production and rRNA pseudouridylation are impaired if any one of the four proteins is depleted. The four H/ACA snoRNP proteins are also components of the telomerase complex. This gene encodes a protein related to Saccharomyces cerevisiae Nhp2p. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2008]

• Gene Synonyms (DKCB2, NHP2P, NOLA2, H/ACA ribonucleoprotein complex subunit 2, NHP2 ribonucleoprotein homolog, NHP2-like protein, nucleolar protein family A, member 2 (H/ACA small nucleolar RNPs), snoRNP protein NHP2,)
• NCBI Gene ID: 55651
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q9NX24
  UNIPROT ID#>>J3QSY4
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

NHP2 ribonucleoprotein interacts with:

• cullin associated and neddylation dissociated 1
  lin-28 homolog A
  lin-28 homolog B
  nuclear assembly factor 1 ribonucleoprotein
  nucleolar protein 12
  UTP23 small subunit processome component
  WD repeat domain 48

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.