SCYL2, SCY1 like pseudokinase 2

SCYL2, SCY1 like pseudokinase 2

• The protein encoded by this gene associates with clathrin-coated complexes at the plasma membrane and with endocytic coated vesicles. The encoded protein phosphorylates the beta2 subunit of the plasma membrane adapter complex AP2 and interacts with clathrin, showing involvement in clathrin-dependent pathways between the trans-Golgi network and the endosomal system. In addition, this protein has a role in the Wnt signaling pathway by targeting frizzled 5 (Fzd5) for lysosomal degradation. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Dec 2015]

• Gene Synonyms (AMCNACC, CVAK104, SCY1-like protein 2, SCY1-like 2, SCY1-like, kinase-like 2, coated vesicle-associated kinase of 104 kDa,)
• NCBI Gene ID: 55681
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A0A0U1RQQ9
  UNIPROT ID#>>Q6P3W7
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

SCY1 like pseudokinase 2 interacts with:

• centrobin, centriole duplication and spindle assembly protein
  DDB1 and CUL4 associated factor 15
  mindbomb E3 ubiquitin protein ligase 1
  pleckstrin homology domain containing A4
  SAP domain containing ribonucleoprotein
  septin 11
  spermatogenesis associated 1
  translocase of outer mitochondrial membrane 22
  transmembrane protein 17
  ubiquitin associated protein 2

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.