TRMU, tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase

TRMU, tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase

• This nuclear gene encodes a mitochondrial tRNA-modifying enzyme. The encoded protein catalyzes the 2-thiolation of uridine on the wobble positions of tRNA(Lys), tRNA(Glu), and tRNA(Gln), resulting in the formation of 5-taurinomethyl-2-thiouridine moieties. Mutations in this gene may cause transient infantile liver failure. Polymorphisms in this gene may also influence the severity of deafness caused by mitochondrial 12S ribosomal RNA mutations. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

• Gene Synonyms (LCAL3, MTO2, MTU1, TRMT, TRMT1, mitochondrial tRNA-specific 2-thiouridylase 1, MTO2 homolog, lung cancer associated lncRNA 3, mitochondrial 5-methylaminomethyl-2-thiouridylate-methyltransferase,)
• NCBI Gene ID: 55687
• Species: Homo sapiens (Human)
• UNIPROT ID#>>O75648
  UNIPROT ID#>>Q2PPL5
  UNIPROT ID#>>Q2PPL4
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase interacts with:

• family with sequence similarity 219 member B
  pleckstrin homology domain containing A4

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