TDP1, tyrosyl-DNA phosphodiesterase 1

TDP1, tyrosyl-DNA phosphodiesterase 1

• The protein encoded by this gene is involved in repairing stalled topoisomerase I-DNA complexes by catalyzing the hydrolysis of the phosphodiester bond between the tyrosine residue of topoisomerase I and the 3-prime phosphate of DNA. This protein may also remove glycolate from single-stranded DNA containing 3-prime phosphoglycolate, suggesting a role in repair of free-radical mediated DNA double-strand breaks. This gene is a member of the phospholipase D family and contains two PLD phosphodiesterase domains. Mutations in this gene are associated with the disease spinocerebellar ataxia with axonal neuropathy (SCAN1). [provided by RefSeq, Aug 2016]

• Gene Synonyms (tyrosyl-DNA phosphodiesterase 1, tyr-DNA phosphodiesterase 1,)
• NCBI Gene ID: 55775
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A0A024R6L5
  UNIPROT ID#>>B3KN41
  UNIPROT ID#>>Q9NUW8
  UNIPROT ID#>>G3V2F4
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

tyrosyl-DNA phosphodiesterase 1 interacts with:

• aprataxin and PNKP like factor
  tyrosyl-DNA phosphodiesterase 1

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