PRRG1, proline rich and Gla domain 1

PRRG1, proline rich and Gla domain 1

• This gene encodes a vitamin K-dependent, gamma-carboxyglutamic acid (Gla)-containing, single-pass transmembrane protein. This protein contains a Gla domain at the N-terminus, preceded by a propeptide sequence required for post-translational gamma-carboxylation of specific glutamic acid residues by a vitamin K-dependent gamma-carboxylase. The C-terminus is proline-rich containing PPXY and PXXP motifs found in a variety of signaling and cytoskeletal proteins. This gene is highly expressed in the spinal cord. Several alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2010]

• Gene Synonyms (transmembrane gamma-carboxyglutamic acid protein 1, proline rich Gla (G-carboxyglutamic acid) 1, proline-rich Gla (G-carboxyglutamic acid) polypeptide 1, PRGP1,)
• NCBI Gene ID: 5638
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q8NEK6
  UNIPROT ID#>>O14668
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

proline rich and Gla domain 1 interacts with:

• F-box protein 25
  NEDD4 like E3 ubiquitin protein ligase
  ubiquinol-cytochrome c reductase hinge protein

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.