PRSS2, serine protease 2

PRSS2, serine protease 2

• This gene belongs to the trypsin family of serine proteases and encodes anionic trypsinogen. It is part of a cluster of trypsinogen genes that are located within the T cell receptor beta locus. Enzymes of this family cleave peptide bonds that follow lysine or arginine residues. This protein is found at high levels in pancreatic juice and its upregulation is a characteristic feature of pancreatitis. This protein has also been found to activate pro-urokinase in ovarian tumors, suggesting a function in tumor invasion. In addition, this enzyme is able to cleave across the type II collagen triple helix in rheumatoid arthritis synovitis tissue, potentially participating in the degradation of type II collagen-rich cartilage matrix. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jan 2015]

• Gene Synonyms (trypsin-2, anionic trypsinogen, protease serine 2 preproprotein, protease, serine 2, protease, serine, 2 (trypsin 2), trypsin II, trypsinogen 2, TRY2, TRY8, TRYP2,)
• NCBI Gene ID: 5645
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q6PK75
  UNIPROT ID#>>Q5NV56
  UNIPROT ID#>>P07478
  UNIPROT ID#>>A6XMV9
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

serine protease 2 interacts with:

• cell death inducing DFFA like effector c
  growth differentiation factor 11
  secretory leukocyte peptidase inhibitor
  solute carrier family 35 member A2
  transmembrane protein 252
  tubulin beta 1 class VI
  tubulin beta 3 class III

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.