DOCK6, dedicator of cytokinesis 6

DOCK6, dedicator of cytokinesis 6

• This gene encodes a member of the dedicator of cytokinesis (DOCK) family of atypical guanine nucleotide exchange factors. Guanine nucleotide exchange factors interact with small GTPases and are components of intracellular signaling networks. The encoded protein is a group C DOCK protein and plays a role in actin cytoskeletal reorganization by activating the Rho GTPases Cdc42 and Rac1. Mutations in this gene are associated with Adams-Oliver syndrome 2. [provided by RefSeq, Dec 2011]

• Gene Synonyms (AOS2, ZIR1, dedicator of cytokinesis protein 6,)
• NCBI Gene ID: 57572
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q96HP0
  UNIPROT ID#>>B7Z9U8
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

dedicator of cytokinesis 6 interacts with:

• centrosomal protein 135
  dedicator of cytokinesis 7
  dedicator of cytokinesis 8
  kinesin family member 7
  kinesin family member C1
  leucine rich repeats and calponin homology domain containing 3
  MOB kinase activator 1B
  zinc finger protein 785

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.