MARCHF4, membrane associated ring-CH-type finger 4

MARCHF4, membrane associated ring-CH-type finger 4

• MARCH4 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). MARCH enzymes add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments. MARCH4 reduces surface accumulation of several membrane glycoproteins by directing them to the endosomal compartment (Bartee et al., 2004 [PubMed 14722266]).[supplied by OMIM, Apr 2010]

• Gene Synonyms (MARCH-IV, MARCH4, RNF174, E3 ubiquitin-protein ligase MARCHF4, E3 ubiquitin-protein ligase MARCH4, RING finger protein 174, RING-type E3 ubiquitin transferase MARCH4, RING-type E3 ubiquitin transferase MARCHF4, membrane associated ring finger 4, membrane-associated RING finger protein 4, membrane-associated RING-CH protein IV, membrane-associated ring finger (C3HC4) 4, E3 ubiquitin protein ligase,)
• NCBI Gene ID: 57574
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q9P2E8
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

membrane associated ring-CH-type finger 4 interacts with:

• UL16 binding protein 1

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