NLRC4, NLR family CARD domain containing 4

NLRC4, NLR family CARD domain containing 4

• This gene encodes a member of the caspase recruitment domain-containing NLR family. Family members play essential roles in innate immune response to a wide range of pathogenic organisms, tissue damage and other cellular stresses. Mutations in this gene result in autoinflammation with infantile enterocolitis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]

• Gene Synonyms (NLR family CARD domain-containing protein 4, CARD, LRR, and NACHT-containing protein, ICE-protease activating factor, NOD-like receptor C4, caspase recruitment domain family, member 12, caspase recruitment domain-containing protein 12, nucleotide-binding oligomerization domain, leucine rich repeat and CARD domain containing 4, AIFEC, CARD12, CLAN, CLAN1, CLANA, CLANB, CLANC, CLAND, CLR2.1, FCAS4, IPAF,)
• NCBI Gene ID: 58484
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q9NPP4
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

NLR family CARD domain containing 4 interacts with:

• NLR family CARD domain containing 4
  NLR family pyrin domain containing 3
  NLR family pyrin domain containing 4
  nucleotide binding oligomerization domain containing 2

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.