RHEB, Ras homolog, mTORC1 binding

RHEB, Ras homolog, mTORC1 binding

• This gene is a member of the small GTPase superfamily and encodes a lipid-anchored, cell membrane protein with five repeats of the RAS-related GTP-binding region. This protein is vital in regulation of growth and cell cycle progression due to its role in the insulin/TOR/S6K signaling pathway. The protein has GTPase activity and shuttles between a GDP-bound form and a GTP-bound form, and farnesylation of the protein is required for this activity. Three pseudogenes have been mapped, two on chromosome 10 and one on chromosome 22. [provided by RefSeq, Jul 2008]

• Gene Synonyms (GTP-binding protein Rheb, Ras homolog enriched in brain 2, RHEB2,)
• NCBI Gene ID: 6009
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A0A090N900
  UNIPROT ID#>>Q15382
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

Ras homolog, mTORC1 binding interacts with:

• adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1
  amyloid beta precursor protein binding protein 2
  ariadne RBR E3 ubiquitin protein ligase 2
  basic leucine zipper nuclear factor 1
  cAMP responsive element binding protein 3
  dual specificity phosphatase 19
  ECSIT signaling integrator
  ectonucleotide pyrophosphatase/phosphodiesterase 7
  FKBP prolyl isomerase 8
  interleukin 20 receptor subunit alpha
  MTOR associated protein, LST8 homolog
  nuclear factor of activated T cells 2 interacting protein
  nuclear receptor subfamily 2 group C member 2
  pleckstrin homology domain containing A4
  Rab acceptor 1
  RAB7A, member RAS oncogene family
  RAB9A, member RAS oncogene family
  regulatory associated protein of MTOR complex 1
  RELT like 2
  ribosomal protein S6 kinase B1
  ring finger protein 152
  solute carrier family 15 member 1
  spermatogenesis associated 19
  SRP receptor subunit beta
  TNF receptor associated factor 2
  TNF receptor-associated factor 2
  transmembrane protein 52B
  tripartite motif containing 25
  TSC complex subunit 1
  TSC complex subunit 2
  tumor necrosis factor
  ubiquitin B
  ubiquitin specific peptidase 4
  vacuolar protein sorting 4 homolog A

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.