- Gene Overview
- Interaction Network
- Sequence Verification
SEMA4A, semaphorin 4A
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This gene encodes a member of the semaphorin family of soluble and transmembrane proteins. Semaphorins are involved in numerous functions, including axon guidance, morphogenesis, carcinogenesis, and immunomodulation. The encoded protein is a single-pass type I membrane protein containing an immunoglobulin-like C2-type domain, a PSI domain and a sema domain. It inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons. It is an activator of T-cell-mediated immunity and suppresses vascular endothelial growth factor (VEGF)-mediated endothelial cell migration and proliferation in vitro and angiogenesis in vivo. Mutations in this gene are associated with retinal degenerative diseases including retinitis pigmentosa type 35 (RP35) and cone-rod dystrophy type 10 (CORD10). Multiple alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Sep 2010]
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Gene Synonyms (semaphorin-4A, sema B, sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A, semaphorin-B, CORD10, RP35, SEMAB, SEMB,)
- NCBI Gene ID:
64218
- Species:
Homo sapiens (Human)
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UNIPROT ID#>>B4DKS5
UNIPROT ID#>>Q9H3S1
- View the NCBI Database
for this Gene »
Gene products are often involved in multiple pathways and networks within a living
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semaphorin 4A interacts with:
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