TBCE, tubulin folding cofactor E

TBCE, tubulin folding cofactor E

• Cofactor E is one of four proteins (cofactors A, D, E, and C) involved in the pathway leading to correctly folded beta-tubulin from folding intermediates. Cofactors A and D are believed to play a role in capturing and stabilizing beta-tubulin intermediates in a quasi-native confirmation. Cofactor E binds to the cofactor D/beta-tubulin complex; interaction with cofactor C then causes the release of beta-tubulin polypeptides that are committed to the native state. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

• Gene Synonyms (tubulin-specific chaperone E, hypoparathyroidism, growth and mental retardation, and dysmorphism, HRD, KCS, KCS1, PEAMO, pac2,)
• NCBI Gene ID: 6905
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q15813
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

tubulin folding cofactor E interacts with:

• 2-oxoglutarate and iron dependent oxygenase domain containing 1
  betaine--homocysteine S-methyltransferase 2
  BICD cargo adaptor 2
  centrosomal protein 19
  chloride channel CLIC like 1
  DnaJ heat shock protein family (Hsp40) member C13
  erythroid differentiation regulatory factor 1
  FYN binding protein 2
  glucosamine-6-phosphate deaminase 1
  interferon regulatory factor 2 binding protein 1
  SERPINE1 mRNA binding protein 1
  surfactant associated 2
  tripartite motif containing 11
  tRNA nucleotidyl transferase 1
  tubulin alpha 4a
  zinc finger C3H1-type containing

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.