TRNT1, tRNA nucleotidyl transferase 1

TRNT1, tRNA nucleotidyl transferase 1

• The protein encoded by this gene is a CCA-adding enzyme which belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. This essential enzyme functions by catalyzing the addition of the conserved nucleotide triplet CCA to the 3' terminus of tRNA molecules. Mutations in this gene result in sideroblastic anemia with B-cell immunodeficiency, periodic fevers, and developmental delay. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]

• Gene Synonyms (CCA tRNA nucleotidyltransferase 1, mitochondrial, ATP(CTP):tRNA nucleotidyltransferase, CCA-adding enzyme, mitochondrial CCA-adding tRNA-nucleotidyltransferase, mt CCA-adding enzyme, mt tRNA CCA-diphosphorylase, mt tRNA CCA-pyrophosphorylase, mt tRNA adenylyltransferase, tRNA CCA nucleotidyl transferase 1, tRNA nucleotidyl transferase, CCA-adding, 1, tRNA-nucleotidyltransferase 1, mitochondrial, CCA1, CGI-47, MtCCA, RPEM, SIFD,)
• NCBI Gene ID: 51095
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A0A024R2H7
  UNIPROT ID#>>Q96Q11
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

tRNA nucleotidyl transferase 1 interacts with:

• 2-oxoglutarate and iron dependent oxygenase domain containing 1
  acyl-CoA thioesterase 13
  asparaginyl-tRNA synthetase 2, mitochondrial
  H2A.Z variant histone 2
  pleckstrin homology domain containing A4
  thioredoxin domain containing 17
  tRNA methyltransferase 10C, mitochondrial RNase P subunit
  ubiquitin like modifier activating enzyme 6

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.