TIE1, tyrosine kinase with immunoglobulin like and EGF like domains 1

TIE1, tyrosine kinase with immunoglobulin like and EGF like domains 1

• This gene encodes a member of the tyrosine protein kinase family. The encoded protein plays a critical role in angiogenesis and blood vessel stability by inhibiting angiopoietin 1 signaling through the endothelial receptor tyrosine kinase Tie2. Ectodomain cleavage of the encoded protein relieves inhibition of Tie2 and is mediated by multiple factors including vascular endothelial growth factor. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]

• Gene Synonyms (tyrosine-protein kinase receptor Tie-1, tyrosine kinase with immunoglobulin and epidermal growth factor homology domains 1, JTK14, TIE,)
• NCBI Gene ID: 7075
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P35590
  UNIPROT ID#>>B4DTW8
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

tyrosine kinase with immunoglobulin like and EGF like domains 1 interacts with:

• angiopoietin 4
  ezrin
  keratin 40
  keratin associated protein 10-8
  myotubularin related protein 14
  RNA binding protein, mRNA processing factor
  thyroid hormone receptor interactor 6
  tyrosine kinase with immunoglobulin like and EGF like domains 1
  zinc finger RANBP2-type containing 1

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.