TNFRSF4, TNF receptor superfamily member 4

TNFRSF4, TNF receptor superfamily member 4

• The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been shown to activate NF-kappaB through its interaction with adaptor proteins TRAF2 and TRAF5. Knockout studies in mice suggested that this receptor promotes the expression of apoptosis inhibitors BCL2 and BCL2lL1/BCL2-XL, and thus suppresses apoptosis. The knockout studies also suggested the roles of this receptor in CD4+ T cell response, as well as in T cell-dependent B cell proliferation and differentiation. [provided by RefSeq, Jul 2008]

• Gene Synonyms (tumor necrosis factor receptor superfamily member 4, ACT35 antigen, ATC35 antigen, CD134 antigen, OX40 antigen, OX40 cell surface antigen, OX40 homologue, OX40L receptor, TAX transcriptionally-activated glycoprotein 1 receptor, lymphoid activation antigene ACT35, tax-transcriptionally activated glycoprotein 1 receptor, ACT35, CD134, IMD16, OX40, TXGP1L,)
• NCBI Gene ID: 7293
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P43489
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

TNF receptor superfamily member 4 interacts with:

• nuclear FMR1 interacting protein 2
  ring finger and CCCH-type domains 1
  SIVA1 apoptosis inducing factor
  TNF receptor associated factor 4

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.