XRCC4, X-ray repair cross complementing 4

XRCC4, X-ray repair cross complementing 4

• The protein encoded by this gene functions together with DNA ligase IV and the DNA-dependent protein kinase in the repair of DNA double-strand breaks. This protein plays a role in both non-homologous end joining and the completion of V(D)J recombination. Mutations in this gene can cause short stature, microcephaly, and endocrine dysfunction (SSMED). Alternate transcript variants such as NM_022406 are unlikely to be expressed in some individuals due to a polymorphism (rs1805377) in the last splice acceptor site. [provided by RefSeq, Oct 2019]

• Gene Synonyms (DNA repair protein XRCC4, X-ray repair complementing defective repair in Chinese hamster cells 4, SSMED,)
• NCBI Gene ID: 7518
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A0A024RAP0
  UNIPROT ID#>>A0A024RAL0
  UNIPROT ID#>>Q7Z763
  UNIPROT ID#>>A0A024RAQ8
  UNIPROT ID#>>Q13426
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

X-ray repair cross complementing 4 interacts with:

• AHNAK nucleoprotein
  amyloid beta precursor protein binding protein 2
  aprataxin
  aprataxin and PNKP like factor
  aspartyl aminopeptidase
  asteroid homolog 1
  caspase activity and apoptosis inhibitor 1
  cullin 1
  CWC27 spliceosome associated cyclophilin
  density regulated re-initiation and release factor
  DnaJ heat shock protein family (Hsp40) member C9
  family with sequence similarity 9 member B
  F-box and WD repeat domain containing 7
  forty-two-three domain containing 1
  HAUS augmin like complex subunit 2
  hydroxysteroid dehydrogenase like 2
  intermediate filament family orphan 1
  intermediate filament family orphan 2
  keratin 27
  kinesin family member 3A
  LON peptidase N-terminal domain and ring finger 2
  mediator complex subunit 4
  myotubularin related protein 7
  non-homologous end joining factor 1
  nudix hydrolase 21
  polynucleotide kinase 3'-phosphatase
  ring finger protein 135
  SIN3-HDAC complex associated factor
  ubiquitin specific peptidase 7
  VPS41 subunit of HOPS complex
  X-ray repair cross complementing 4
  X-ray repair cross complementing 5

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.