MAFK, MAF bZIP transcription factor K

MAFK, MAF bZIP transcription factor K

• The developmentally regulated expression of the globin genes depends on upstream regulatory elements termed locus control regions (LCRs). LCRs are associated with powerful enhancer activity that is mediated by the transcription factor NFE2 (nuclear factor erythroid-2). NFE2 recognition sites are also present in the gene promoters of 2 heme biosynthetic enzymes, porphobilinogen deaminase (PBGD; MIM 609806) and ferrochelatase (FECH; MIM 612386). NFE2 DNA-binding activity consists of a heterodimer containing an 18-kD Maf protein (MafF, MafG (MIM 602020), or MafK) and p45 (MIM 601490). Both subunits are members of the activator protein-1 superfamily of basic leucine zipper (bZIP) proteins (see MIM 165160). Maf homodimers suppress transcription at NFE2 sites.[supplied by OMIM, Nov 2008]

• Gene Synonyms (transcription factor MafK, basic-leucine zipper transcription factor MafK, erythroid transcription factor NF-E2 p18 subunit, nuclear factor erythroid-2, ubiquitous (p18), v-maf avian musculoaponeurotic fibrosarcoma oncogene family, protein K, v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog K, v-maf musculoaponeurotic fibrosarcoma oncogene homolog K, NFE2U, P18,)
• NCBI Gene ID: 7975
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A0A024R804
  UNIPROT ID#>>O60675
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

MAF bZIP transcription factor K interacts with:

• BTB and CNC homology 1, basic leucine zipper transcription factor 1
  BTB domain and CNC homolog 2
  cullin 4A
  DNA methyltransferase 3 like
  H4 clustered histone 1
  histone deacetylase 3
  lysine acetyltransferase 6A
  MAF bZIP transcription factor K
  nuclear factor, erythroid 2 like 3

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