UBXN8, UBX domain protein 8

UBXN8, UBX domain protein 8

• p97 or VCP (valosin-containing protein) is a versatile ATPase complex, and many cofactors are required for the p97 functional diversity. This gene encodes one of the p97 cofactors. This cofactor is a transmembrane protein and localized in the endoplasmic reticulum (ER) membrane. It tethers p97 to the ER membrane via its UBX domain. The association of this cofactor with p97 facilitates efficient ER-associated degradation of misfolded proteins. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2013]

• Gene Synonyms (UBX domain-containing protein 8, Reproduction/chromosome 8, UBX domain-containing protein 6, rep-8 protein, reproduction 8 protein, D8S2298E, REP8, UBXD6,)
• NCBI Gene ID: 7993
• Species: Homo sapiens (Human)
• UNIPROT ID#>>O00124
  UNIPROT ID#>>B4DKK1
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

UBX domain protein 8 interacts with:

• complement component 5a receptor 2
  egl-9 family hypoxia inducible factor 3
  hydroxysteroid 17-beta dehydrogenase 13
  mitochondrial carrier 2
  NPL4 homolog, ubiquitin recognition factor
  nuclear RNA export factor 1
  OTU deubiquitinase with linear linkage specificity like
  progesterone receptor membrane component 2
  rhomboid domain containing 2
  selenoprotein S
  signal peptidase complex subunit 1
  solute carrier family 38 member 1
  succinate-CoA ligase ADP-forming subunit beta
  synoviolin 1
  TBC1 domain family member 15
  TBC1 domain family member 17
  transmembrane protein 14B
  transmembrane protein 165
  valosin containing protein interacting protein 1

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.